Evaluation of copper, zinc and ceruloplasmin concentrations in patients with brucellosis and their comparison with the control group in eastern Guilan province during 2022-2023

Document Type : Research Article

Authors

• Asiyeh Saber
• Elmira Ghadiri
• Khosro Issazadeh

Department of Microbiology, La.C., Islamic Azad University, Lahijan, Iran

10.22034/ijmcm.2024.710206

Abstract

Brucellosis is one of the most important and zoonosis common diseases between humans and animals. The metabolism of trace elements such as zinc, copper, and ceruloplasmin can influence the immune system response and activate the host's immunochemical mechanisms against this organism. Accordingly, this study aimed to evaluate copper, zinc, and ceruloplasmin concentrations in patients with brucellosis . This descriptive, cross-sectional study was conducted on 32 patients with brucellosis who had referred to medical centers in eastern Guilan province and 32 people from the control group. Copper levels in the serum of patients and controls were measured according to the biochemical protocol kit with code REF 10-564, zinc levels according to the biochemical protocol kit with code REF 10-517, and ceruloplasmin levels according to the biochemical protocol kit with code MAK 177. In this study, the average copper levels in test and control group were 98 ± 4.14 g/dl and 76 ± 5.12 g/dl respectively, the average zinc levels in test and control group were 44 ± 3.28 g/dl and 72 ± 3.15 g/dl respectively, the average ceruloplasmin levels in test and control group were 40 ± 8.10 g/dl and 31 ± 11.1 g/dl, and the copper to zinc ratio in the patients with brucellosis was 2.22 ± 0.5 and 1.05 ± 8 in the control group. Therefore, it was determined that there was a significant difference between the average levels of copper, zinc, ceruloplasmin, and the ratio of copper to zinc in people with brucellosis and the control group.

Keywords

• Keywords: Brucellosis
• Copper
• Zinc
• Ceruloplasmin
• Malta fever

Main Subjects

• Clinical Microbiology

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