Study of the effect of inactivated Salmonella vaccine in broiler breeder flocks and their progenies in the prevention and control of Salmonella

Document Type : Research Article

Authors

• Mohammad N Ghahremani ¹
• Mohammad Moafi ²
• Kaveh Parvandar Asadollahi ³

¹ Department of Clinical Sciences, Faculty of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran.

² Department of Veterinary Pathobiology, SR.C., Islamic Azad University, Tehran, Iran

³ Department of Clinical Sciences, College of Veterinary Medicine, Science and Research Branch, Islamic Azad University, Tehran, Iran

10.22034/ijmcm.2025.2009823.1331

Abstract

Salmonellosis is one of the most prevalent diseases causing gastroenteritis and diarrhea in both humans and animals. Salmonella has over 2,500 known serotypes; Typhimurium, Enteritidis, and Infantis are known to be the most frequently isolated ones in outbreaks worldwide. We can reduce the incidence of salmonellosis and prevalence of Salmonella in humans with managing and controlling salmonellosis in poultry farms. One of the most effective ways for preventing salmonellosis in poultry is vaccination. The current study was set out to evaluate the efficacy of an inactivated Salmonella vaccine in flocks of one broiler breeder farm with a capacity of 40000 chickens located in Gilan province in 2024 and 2025, which contains inactivated strains of S. Typhimurium and S. Enteritidis. Serological titers were measured via an ELISA kit in the flock and its offspring. High serological titers were detected in both groups. A one-way ANOVA showed significant differences in breeder titers across sampling times (p < 0.001), with mean values ranging from 2295 to 5208, and the offspring had an average titer of 1629. Results suggest that passive antibody transfer and increased immune response likely occurred. In addition, there were no Salmonella detections from the breeder flock up to 60 weeks and from the offspring of one-day-old. These findings indicate that inactivated vaccines may play a crucial role in controlling and preventing Salmonella in breeder flocks and their offspring, and can help us in public health and the enhancement of food safety.

Keywords

• Salmonella control
• breeder flock
• Poultry vaccination
• inactivated vaccine
• Food safety

Main Subjects

• Antimicrobial agents

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